Name：Yu-ai Yang
Professional title：Professor
Research focus：Clinical Veterinary Medicine
Tutor category：£PhD Supervisor RMaster Supervisor
E-mail address：yangyuai2008@126.com
Education
From 2004-09 to 2007-06, Northwest Agriculture and Forestry University, Clinical veterinary medicine, Doctor
From 2001-09 to 2004-06, Northwest Agriculture and Forestry University, Clinical veterinary medicine, Master
From 1997-09 to 2001-06, Northwest Agriculture and Forestry University, Veterinary Medicine, Bachelor
Career
From 2021-12 up to now, Yunnan agriculture university, College of animal medicine, Professor
From 2011-10 to 2021-11, Yunnan agriculture university, College of animal science and technology, Associate professor
From 2007-07 to 2011-09, Yunnan agriculture university, College of animal science and technology, Lecturer
Courses
1. Animal Surgery
2. Veterinary Medicine
3. Veterinary Obstetrics
Research focus
1. Clinical Veterinary Medicine
2. Animal Surgery
Research & Teaching
Research projects
National Natural Science Foundation of China, Regional Science Foundation Project，31760743，The molecular mechanisms of the transmembrane protein at tight junctions CLDN-1 during Classic Swine Fever Virus Infection, From 2018-01 to 2021-12, RMB 370000, Finished, Principle Investigator.
National Natural Science Foundation of China, Regional Science Foundation Project，32160845，Molecular mechanism of mutated gene Mut of yunnan strain of atypical swine fever virus to regulate host NF-κB activity, From 2022-01 to 2025-12, RMB 360000, Under research, Participants.
Department of science and technology of Yunnan Province, Natural science and technology projects in Yunnan Province，2009CD063，Study on the pathogenesis of mastitis in dairy cows in Kunming area，From 2009-01 to 2012-12, RMB 75000, Finished, Principle Investigator.
Yunnan agriculture university, Natural Science Youth Research Fund of the University, 2016ZR12，Molecular mechanisms by which atypical swine fever virus affects immune function in pigs，From 2017-01 to 2019-12, RMB 50000, Finished, Principle Investigator.
Zhong mu Industrial Co., Ltd. and so on, Enterprise cooperation research and development projects, 2021533517000971，Research and development of swine fever virus human type 5 replication-deficient adenovirus vector live vaccine (rAd-E0-E2 strain), From 2021.10 to 2041.09, RMB 8.3 million, Under research, Principle Investigator.
Shandong Zhu zi Biotechnology Co., Ltd and so on, Enterprise cooperation research and development projects, 2021533517000585，Research and development of a live binary vaccine for swine fever recombinant adenovirus (rAd-E0-E2 strain)-porcine pseudorabies gene deletion virus (JS-2012), From 2021.07 to 2041.06, RMB 3.5 million, Under research, Principle Investigator.
Teaching projects
Yunnan agriculture university, Undergraduate Education Teaching Reform Project, 2017YAUJY013，Experimental teaching reform in《Animal Surgery》, From 2017-07 to 2019-06, RMB 5000, Finished, Principle Investigator.
Yunnan agriculture university, Projection of Professional Degree Graduate Program Case Library Construction, Biotechnology and Livestock and Poultry Disease Diagnosis Case Library, From 2017-07 to 2020-06, RMB 30000, Finished, Principle Investigator.
Representative achievements
Development of a novel vaccine for swine fever: The recombinant human type 5 replication deficient adenovirus expressing CSFV E0 and E2 genes has been developed, and has completed the safety evaluation of genetically modified organisms by the Ministry of Agriculture. It has obtained the agricultural genetically modified organism safety certificate from the Ministry of Agriculture, and has signed cooperative development agreements with three domestic vaccine companies. Clinical application work is currently underway.
Journal Publications
Y. Sun, H. Zheng, D. Xi, X. Zhang, M. Du, L. Pu, M. Lin & Y. Yang. Molecular characteristics of the MHC-DRA genes from yak (Bos grunniens) and Chinese yakow (Bos grunniens × Bos taurus), International Journal of Immunogenetics, 2014, 41: 69-73.
Yong-ke Sun, Yu-ai Yang, Huan-li Zheng, Dong-mei Xi, Ming-xing Lin, Xiao-min Zhang, Lin-fu Yang, Yu-lin Yan, Xiao-hui Chu, Bao-liang Bi. Co-expression of Erns and E2 genes of classical swine fever virus by replication-defective recombinant adenovirus completely protects pigs against virulent challenge with classical swine fever virus, Research in Veterinary Science, 2012, 94:354-360.
Sun YK, Zhang XM, Du M, Li, YX, Pan HB, Yan, YL, and Yang, Y.A*. Atypical Classical Swine Fever Infection Changes Interleukin Gene Expression in Pigs Israel Journal of Veterinary Medicine, Israel Journal of Veterinary Medicine, 2014, 69(4):226-231.
Yong-ke Sun, Xiao-min Zhang, Min Du, Yu-Xin Li, Ling-fu Kong, Hong-Bin Pan, Yu-Lin Yan and Yu-ai Yang. Construction of a Chimeric Virus Expressing Mutation Sequences of Classical Swine Fever Virus Yunnan Strain, Journal of Animal and Veterinary Advances, 2014, 13(7):470-476.
Yongke Sun, Dongmei Xi, Guozhi Li, Tiantian Hao, Yuhan Chen and Yuai Yang*. Genetic characterization of MHC class II DQB exon 2 variants in gayal (Bos frontalis) , Biotechnology and Biotechnological Equipment, 2014, 28(5):827-833.
Heng Zhang # , Yong-ke Sun# ,Xiao-miao Zhang, Hui Zhang, Gen-cheng Fan, Yu-lin Yan, Yu-ai Yang*. A Rabbit model for evaluating the efficacy of recombinant adenovirus vaccine expressing E0-E2 antigens of classical swine fever virus, Thai Journal of Veterinary Medicine, 2017. 47(3): 363-372.
Xiangmin Wang, Yu'ai Yang, Xiaoying Yang, Xiao Liua, Xiaochun Wang, Libo Gao, Chao Yang, Rui Lan, Junlong Bi, Qian Zhao, Guishu Yang, Jing Wang, Yingbo Lin, Jianping Liu,*, Gefen Yin,**. Classical swine fever virus infection suppresses claudin-1 expression to facilitate its replication in PK-15 cells Microbial Pathogenesis, 2021 May;157. DOI: 10.1016/j.micpath.2021.105012
Patents
Yong-ke Sun, Yu-ai Yang, A recombinant adenovirus expressing the genes E0 and E2 of swine fever viruses，2013-01-02, China，ZL201110000978.4.
Words for students
If you see the shadow in front of, don’t be afraid, that’s because you have the sun behind！