Name：Yong-ke Sun
Professional title：Professor
Research focus：Preventive Veterinary Medicine
Tutor category：£PhD Supervisor RMaster Supervisor
E-mail address：
Education
From 2004-09 to 2007-06, Northwest Agriculture and Forestry University, preventive veterinary medicine, Doctor
From 2001-09 to 2004-06, Northwest Agriculture and Forestry University, preventive veterinary medicine, Master
From 1997-09 to 2001-06, Northwest Agriculture and Forestry University, Veterinary Medicine, Bachelor
Career
From 2016-19 up to now, Yunnan agriculture university, College of animal medicine, Professor
From 2010-10 to 2016-09, Yunnan agriculture university, College of animal science and technology, Associate professor
From 2007-07 to 2010-09, Yunnan agriculture university, College of animal science and technology, Lecturer
Courses
1. Animal Quarantine and Inspection
2. Veterinary Biological Products
Research focus
1. Molecular pathogens and molecular immunology
2. Animal Epidemiology
Research & Teaching
Research projects
National Natural Science Foundation of China, Regional Science Foundation Project，32160845，Molecular mechanism of mutated gene of Yunnan strain of atypical swine fever virus to regulate host NF-κB activity, From 2022-01 to 2025-12, RMB 360000, Under research, Principle Investigator.
National Natural Science Foundation of China, Regional Science Foundation Project，31560704，The Yunnan strain of atypical swine fever virus regulates the ASC-mediated inflammatory signaling pathway mechanisms of vascular endothelial cells, From 2016-01 to 2019-12, RMB 410000, Finished, Principle Investigator.
National Natural Science Foundation of China, Regional Science Foundation Project，30960285，Molecular mechanism of atypical swine fever caused by Yunnan strain of swine fever virus, From 2009-01 to 2012-12, RMB 240000, Finished, Principle Investigator.
Department of science and technology of Yunnan Province, Natural science and technology projects in Yunnan Province，2008CD134，Immunological characteristics of swine fever virus E0/E2 gene recombinant adenovirus vaccine，From 2008-01 to 2011-12, RMB 75000, Finished, Principle Investigator.
Qingdao Yi bang Biological Engineering Co., Ltd, Enterprise cooperation research and development projects, KX132201, Research and development of swine fever adenovirus vector vaccine, From 2012-01 to 2014-12, RMB 2.0 million, Finished, Principle Investigator.
Qian yuan-hao Biological Co., Ltd, Enterprise cooperation research and development projects, KX132141，Research and development of swine fever adenovirus vector vaccine, From 2014-01 to 2017-12, RMB 2.0 million, Finished, Principle Investigator.
Yunnan Biotechnology Co., Ltd, Enterprise cooperation research and development projects, KX140540，Co-expression of swine fever virus E2 gene and blue ear disease virus GP5 gene recombinant adenovirus vaccine construction, From 2009-01 to 2011-12, RMB 500000, Finished, Principle Investigator.
Qingdao Yi bang Biological Engineering Co., Ltd, Enterprise cooperation research and development projects, KX132135, Strategic cooperation in vector vaccine research and production and transformation, From 2012-07 to 2014-12, RMB 300000, Finished, Principle Investigator.
Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Open Fund of the State Key Laboratory of Pathogenic Biology of Livestock Diseases, SKLVEB2012KFKT005，Molecular mechanisms by which atypical swine fever virus affects immune function in pigs，From 2012-01 to 2014-12, RMB 60000, Finished, Principle Investigator.
Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Open Fund of the State Key Laboratory of Veterinary Biotechnology, HBVEB2012KFKT003，Effects of atypical swine fever virus on the body's immune function，From 2012-01 to 2014-12, RMB 120000, Finished, Principle Investigator.
Teaching projects
Yunnan agriculture university, Undergraduate Education Teaching Reform Project, XYJG201320，Research on the Teaching Reform Scheme of the Curriculum《Animal Quarantine》, From 2012-01 to 2014-12, RMB 5000, Finished, Principle Investigator.
Representative achievements
Development of a novel vaccine for swine fever: The recombinant human type 5 replication deficient adenovirus expressing CSFV E0 and E2 genes has been developed, and has completed the safety evaluation of genetically modified organisms by the Ministry of Agriculture. It has obtained the agricultural genetically modified organism safety certificate from the Ministry of Agriculture, and has signed cooperative development agreements with three domestic vaccine companies. Clinical application work is currently underway.
Journal Publications
Y. Sun, H. Zheng, D. Xi, X. Zhang, M. Du, L. Pu, M. Lin & Y. Yang. Molecular characteristics of the MHC-DRA genes from yak (Bos grunniens) and Chinese yakow (Bos grunniens × Bos taurus), International Journal of Immunogenetics, 2014, 41: 69-73.
Yong-ke Sun, Yu-ai Yang, Huan-li Zheng, Dong-mei Xi, Ming-xing Lin, Xiao-min Zhang, Lin-fu Yang, Yu-lin Yan, Xiao-hui Chu, Bao-liang Bi. Co-expression of Erns and E2 genes of classical swine fever virus by replication-defective recombinant adenovirus completely protects pigs against virulent challenge with classical swine fever virus, Research in Veterinary Science, 2012, 94:354-360.
Sun, Y.K., Zhang, X.M., Du, M., Li, Y.X., Pan, H.B., Yan, Y.L., and Yang, Y.A. *.Atypical Classical Swine Fever Infection Changes Interleukin Gene Expression in Pigs Israel Journal of Veterinary Medicine, Israel Journal of Veterinary Medicine, 2014, 69(4):226-231.
Yong-ke Sun, Xiao-min Zhang, Min Du, Yu-Xin Li, Ling-fu Kong, Hong-Bin Pan, Yu-Lin Yan and Yu-ai Yang. Construction of a Chimeric Virus Expressing Mutation Sequences of Classical Swine Fever Virus Yunnan Strain, Journal of Animal and Veterinary Advances, 2014, 13(7):470-476.
Yongke Sun, Dongmei Xi, Guozhi Li, Tiantian Hao, Yuhan Chen and Yuai Yang*. Genetic characterization of MHC class II DQB exon 2 variants in gayal (Bos frontalis) , Biotechnology and Biotechnological Equipment, 2014, 28(5):827-833.
Heng Zhang # , Yong-ke Sun# ,Xiao-miao Zhang, Hui Zhang, Gen-cheng Fan, Yu-lin Yan, Yu-ai Yang *. A Rabbit model for evaluating the efficacy of recombinant adenovirus vaccine expressing E0-E2 antigens of classical swine fever virus, Thai Journal of Veterinary Medicine, 2017. 47(3): 363-372.
Patents
Yong-ke Sun, Yu-ai Yang, A recombinant adenovirus expressing the genes E0 and E2 of swine fever viruses，2013-01-02, China，ZL201110000978.4.
Words for students
As long as you are willing to work hard, you will definitely get the life you want!