Name：Liu Yaowen
Professional title：Assistant professor
Research focus：Genetics
Tutor category：☑ PhD Supervisor £Master Supervisor £Neither
E-mail address：yaowenliu@foxmail.com
Education
Doctor of philosophy (2012-2018)
- Major: Genetics
- China academy of sciences
Master of Biology (2009 -2012)
- Major: Biochemistry and Molecular Biology
- Southwest University
- Supervisor: Prof. Qing-you Xia
Bachelor of Engineering (2005-2009)
- Major: Bioengineering
- Nanjing University of science and technology
Career
2018- up to present，Yunnan agricultural university
Courses
1. Animal ethology
2. Animal Welfare
3.special english
4.scientific writing
5.bioinformatics
Research focus
Mainly engaged in bioinformatics research, specific research directions include
(1) Animal genome research, including genome and evolutionary research on domestic animals such as pigs, chickens, and marine organisms, jellyfish, etc.
(2) Research on genetic factors of diseases and traits, such as domestic animal meat quality, cancer and other genetic factors
Research & Teaching
Research projects
(1) Yunnan Provincial Department of Science and Technology, Agricultural Basic Research Joint Special Project - General Project (202101BD070001-104), Genome Construction and Character Genetic Factor Analysis of Banna Mini Pig Inbred Lines 2022-01-01 to 2024-12-31, 100,000 , host
(2) Yunnan Provincial Department of Science and Technology, General Project, Research on the role of CBX4 gene in the embryonic development of somatic cell nuclear transfer in inbred pigs (202201AT070248), 2022-06-01 to 2025-05-31, 100,000, in charge
(3) Yunnan Provincial Department of Education, Scientific Research Fund Project, Transcriptome Study on the Effect of Oocyte Size on Somatic Cell Nuclear Transfer Efficiency (2019J0150), 2020/1-2021/12, 20,000, Host
(4) National Natural Science Foundation of China, Major Research Plan (91749109), Research on genomic DNA methylation modification patterns and functional effects of healthy and long-lived people in China, 2018-01-01 to 2020-12-31, 600,000 yuan, participation
(5) Ministry of Science and Technology of the People’s Republic of China, National Key Basic Research Project (973 Plan), National Key R&D Plan “Construction and Preclinical Research of Humanized Gene-Edited Donor Pigs for Xenotransplantation” (2019YFA011070), 27.71 million, 2019 Participate from November 2020 to December 2023;
(7) National Natural Science Foundation of China, Regional Science Fund Project, 32160793, Differential expression of 1 ncRNA in in vitro maturation of porcine oocytes after vitrification, 2022-01-01 to 2025-12-31, 350,000 Yuan, participate
(8) National Natural Science Foundation of China, Regional Science Fund Project, 32060206, Research on the mechanism of FIT2 regulating the occurrence and development of very low-density lipoprotein, 2021-01-01 to 2024-12-31.36 million yuan, participation
(9) National Natural Science Foundation of China General Project, 91749109, Research on genomic DNA methylation modification patterns and functional effects of healthy and long-lived people in China, 2018/1-2020/12, 600,000, participation
(10) National Natural Science Foundation of China Youth Project, 81701394, Research on the role and mechanism of low-expression gene LEF1 specific for longevity people in delaying stem cell aging, 2018/1-2020/12,200,000, participation
(11) National Natural Science Foundation of China Youth Project, 81500670, Research on the role and mechanism of heat shock protein 70 (HSP-70) in the occurrence of obesity, 2016/1-2018/12,180,000 yuan, participation
(12) National Natural Science Foundation of China Youth Project, 31000981, Cloning and functional analysis of the promoter of the silkworm fat body-specific expression gene (BmLP3) and its application in bioreactors, 2011/1-2013/12, 200,000 yuan ,participate
Teaching projects
Awards & Honors
Representative achievements
Journal Publications
（1）Yao-Wen Liu#, Yong-Han He#, Yun-Xia Zhang, Wang-Wei Cai, Li-Qin Yang, Liang-You Xu*, Qing-Peng Kong*. Absence of A673T variant in APP gene indicates an alternative protective mechanism contributing to longevity in Chinese individuals. Neurobiology of Aging 2014;35(4):935.e11–12.
（2）Hanfu Xu#, Yaowen Liu#, Feng Wang, Lin Yuan, Yuancheng Wang, Sanyuan Ma, Helen Beneš*, Qingyou Xia*. Overexpression and functional characterization of an Aspergillus nigerphytase in the fat body of transgenic silkworm, Bombyx mori. Transgenic Research 2014;23(4):669–677.
（3）Wang-Xiao Xia#, Lin-Heng Zhang, Yao-Wen Liu*. Weighted Gene Co-Expression Network Analysis Reveals Six Hub Genes Involved in and Tight Junction Function in Pancreatic Adenocarcinoma and their Potential Use in Prognosis. Genetic Testing and Molecular Biomarkers 2019; 23(12):829–836.
（4）Xia, Wangxiao#, Haorong Li, Wenmin Cheng, Honghui Li, Yajing Mi, Xingchun Gou*, Yaowen Liu*. "High-quality genome assembly of Chrysaora quinquecirrha provides insights into the adaptive evolution of jellyfish." Frontiers in Genetics 11 (2020): 535
（5）Wangxiao Xia#, Haorong Li, Jinghao Ge, Yaowu Liu, Peng Liu, Lan Wang, Zhongying Qiu, Honghui Li, Yanhua Su,Haizhen Wang, Yaowen Liu*, Xingchun Gou*. "High-continuity genome assembly of jellyfish (Chrysaora quinquecirrha)." Zoological Research,2021 42, no. 1 (2021): 130.
（6）Xia, Wangxiao#, Hui Jiang, Huifang Guo, Yaowen Liu*, Xingchun Gou*. "Integrated gene co-expression network analysis reveals unique developmental processes of Aurelia aurita." Gene 840 (2022): 146733.
（7）Yong-Han He, Xiao-Qiong Chen, Dong-Jing Yan, Fu-Hui Xiao, Yao-Wen Liu, Rong Lin, Xiao-Ping Liao, Wang-Wei Cai, Qing-Peng Kong. Thyroid function decreases with age and may contribute to longevity in Chinese centenarians’ families. Journal of the American Geriatrics Society 2015, 63, 1474-1476.
（8）Yong-Han He, Shao-Yan Pu, Fu-Hui Xiao, Xiao-Qiong Chen, Dong-Jing Yan, Yao-Wen Liu, Rong Lin, Xiao-Ping Liao, Qin Yu, Li-Qin Yang, Xing-Li Yang, Ming-Xia Ge, Ying Li, Jian-Jun Jiang, Wang-Wei Cai, Qing-Peng Kong Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families[J]. Scientific reports, 2016, 6: 21962.
（9）Yong-Han He , Shao-Yan Pu , Wen Li, Xiao-Qiong Chen , Fu-Hui Xiao , Dong-Jing Yan, Yao-Wen Liu ,Rong Lin, Xiao-Ping Liao, Xing-Li Yang, Ming-Xia Ge, Wang Wei Cai, Qing-Peng Kong. Decline In Blood Hemoglobin Concentration Is Associated With Familial Longevity[J]. Archives of Biological Sciences, 2016, 68(3): 533-540.
（10）Yong-Han He, Xiao-Qiong Chen, Dong-Jing Yan, Fu-Hui Xiao, Rong Lin,Xiao-Ping Liao, Yao-Wen Liu, Shao-Yan Pu Familial longevity study reveals a significant association of mitochondrial DNA copy number between centenarians and their offspring. [J] Neurobiology of aging, 2016,47, 218-e11.
（11）Kumpei Tanisawa, Yasumichi Arai, Nobuyoshi Hirose, Hiroshi Shimokata, Yoshiji Yamada, Hisashi Kawai, Motonaga Kojima, Shuichi Obuchi, Hirohiko Hirano, Hideyo Yoshida, Hiroyuki Suzuki, Yoshinori Fujiwara, Kazushige Ihara, Maki Sugaya, Tomio Arai, Seijiro Mori, Motoji Sawabe, Noriko Sato,Masaaki Muramatsu, Mitsuru Higuchi, Yao-Wen Liu, Qing-Peng Kong, and Masashi Tanaka Exome-wide association study identifies clec3b missense variant p. s106g as being associated with extreme longevity in east asian populations[J]. The Journals of Gerontology: Series A, 2017, 72(3): 309-318.
（12）Fu-Hui Xiao, Xiao-Qiong Chen, Qin Yu, Yunshuang Ye, Yaowen Liu, Dongjing Yan, Li-Qin Yang, Guijun Chen, Rong Lin, Liping Yang, Xiaoping Liao, Wen Zhang, Wei Zhang, Nelson Leung-Sang Tang, Xiao-Fan Wang, Jumin Zhou, Wang-Wei Cai, Yong-Han He and Qing-Peng Kong*, Transcriptome evidence reveals enhanced autophagy-lysosomal function in centenarians, Genome Research, 2018, 28(11):1601-1610.
（13）Wang-Xiao Xia, Qin Yu, Gong-Hua Li, Yao-Wen Liu, Fu-Hui Xiao, Li-Qin Yang, Zia Ur Rahman, Hao-Tian Wang, and Qing-Peng Kong. Identification of four hub genes associated with adrenocortical carcinoma progression by WGCNA[J]. PeerJ, 2019, 7: e6555.
(14) Xu Hanfu, Ma Sanyuan, Wang Feng, Liu Yaowen & Xia Qingyou. (2011). Silkworm egg diapause elimination method suitable for practical transgenic silkworm varieties. Sericulture Science (01), 64-68.
(15) Zhang Ke, Yan Jimeng, Liu Yaowen, Li Honghui, Chen Qiang, Li Zhuo, Su Yanhua, Pu Shaoxia, Wang Haizhen, Wei Hongjiang, Jia Baoyu, Cheng Wenmin. (2021). Expression profile of miRNAs and Npm2 gene in porcine GV/MⅡ stage oocytes Screening of related miRNAs. Journal of Animal Husbandry and Veterinary Medicine (04), 996-1009.
Published books
Patents
Words for students
. stay hungry stay foolish